![]() Patients in the early stages of Lyme disease and those who have been treated with antibiotics may not exhibit detectable antibody titers. Performance characteristics have not been established for the following specimen characteristics:Ī negative result does not exclude the possibility of infection with Borrelia burgdorferi. In selected cases, documentation of infection may be attempted by animal inoculation or PCR methods (LBAB / Babesia species, Molecular Detection, PCR, Blood) Previous episodes of babesiosis may produce a positive serologic result. Other members of the Ehrlichia genus (eg, Ehrlichia ewingii) may not be detected by this assay. Therefore, a single time point-positive titer needs to be interpreted alongside other findings to differentiate recent versus past infection. IgG-class antibodies may remain detectable for months to years following prior infection. Serology results for IgG may be negative during the acute phase of infection (<7 days post-symptom onset), during which time detection using targeted nucleic acid amplification testing (eg, polymerase chain reaction: PCR) is recommended.ĭetectable IgG-class antibodies typically appear within 7 to 10 days post-symptom onset. Supplemental testing by immunoblot has been ordered by reflex.Įhrlichia chaffeensis and Anaplasma phagocytophilum: If recent exposure is suspected, a second sample should be collected and tested in 2 to 4 weeks.Įquivocal or Positive: Not diagnostic. False-negative results may occur in recently infected patients (< or =2 weeks) due to low or undetectable antibody levels to B burgdorferi. Negative: No evidence of antibodies to Borrelia burgdorferi detected. Patients with documented infections have usually had titers ranging from 1:320 to 1:2560. In general, the higher the titer, the more likely it is that the patient has an active infection. Previous episodes of ehrlichiosis may produce a positive serology result although antibody levels decline significantly during the year following infection.Ī positive result of an indirect fluorescent antibody test (titer > or =1:64) suggests current or previous infection with Babesia microti. Four-fold rises in titer also indicate active infection. In general, the higher the titer, the more likely the patient has an active infection. A positive immunofluorescence assay result (titer > or =1:64) suggests current or previous infection.
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